研究与证据转化

Cochrane China Center, MAGIC China Center, and ISPOR West China Chapter are conducting dynamic and synergic research projects by combing their particular strengths. In the past decade, Cochrane China Center has developed a track record in developing and applying novel systematic review and trial methods to assess effects of healthcare interventions, particularly drugs, medical devices, and procedures. MAGIC China Center has become a leading organization that develops rapid guideline recommendations using an established methodological framework. ISPOR West China Chapter has taken innovative approaches to combine the strengths of systematic reviews and other methods tools to assess outcomes of drugs and medical devices. Together, these efforts aim to inform healthcare practice and policy decisions, including guideline development, and regulatory and coverage decisions.

Recently, Cochrane China Center, together with MAGIC China Center, has specfically developed a task force, Rapid Systematic Reviews and Evidence Translation Working Group, that convenes experienced experts across the country and aims to timely produce evidence to support health care and policy decisions.

Our researchers have been productive in generating new knowledge and methods. The following lists a selected collection of academic publications in the past several years.

Methodological Studies
Systematic Reviews and Meta-analyses
  • Xiong Y-Q, Tan J, Liu Y-M, Li Y-Z, You F-F, Zhang M-Y, Chen Q, Zou K, Sun X. Diagnostic accuracy of optical coherence tomography for bladder cancer: A systematic review and meta-analysis. Photodiagnosis and photodynamic therapy. 2019.27:298-304.
  • Xiong Y-Q, Tan J, Liu Y-M, He Q, Li L, Zou K, Sun X. The risk of maternal parvovirus B19 infection during pregnancy on fetal loss and fetal hydrops: A systematic review and meta-analysis. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2019.114:12-20.
  • Jia P, Zhao P, Chen J, Zhang M. Evaluation of clinical decision support systems for diabetes care: An overview of current evidence. Journal of evaluation in clinical practice. 2019.25(1):66-77.
  • Wang W, Chen W, Liu Y, Siemieniuk R A C, Li L, Martínez J P D, Guyatt G H, Sun X. Antibiotics for uncomplicated skin abscesses: systematic review and network meta-analysis. BMJ open. 2018.8(2):e020991-e020991.
  • Tan J, Mao X, Zhang G, Wang W, Pan T, Liu X, Sun X. Hepatitis B surface antigen positivity during pregnancy and risk of gestational diabetes mellitus: A systematic review and meta-analysis. Journal of viral hepatitis. 2018.25(11):1372-1383.
  • Jia P-L, Zhang C, Yu J-J, Xu C, Tang L, Sun X. The risk of lung cancer among cooking adults: a meta-analysis of 23 observational studies. Journal of cancer research and clinical oncology. 2018.144(2):229-240.
  • Chen W, Yu J, Tao H, Cai Y, Li Y, Sun X. Motherwort injection for preventing postpartum hemorrhage in pregnant women with cesarean section: A systematic review and meta-analysis. Journal of evidence-based medicine. 2018.11(4):252-260.
  • Zhou X, Wu X, Sun H, Li J. Efficacy and safety of eptifibatide versus tirofiban in acute coronary syndrome patients: A systematic review and meta-analysis. Journal of evidence-based medicine. 2017.10(2):136-144.
  • Zhao P, Li Y, Li Z, Jia P, Zhang L, Zhang M. Use of patient safety culture instruments in operating rooms: A systematic literature review. Journal of evidence-based medicine. 2017.10(2):145-151.
  • Wang W, Zhou X, Kwong J S W, Li L, Li Y, Sun X. Efficacy and safety of thiazolidinediones in diabetes patients with renal impairment: a systematic review and meta-analysis. Scientific reports. 2017.7(1):1717-1717.
  • Wang W, Gao Y, Chen D, Wang C, Feng X, Ran X. Efficacy and safety of incretin-based drugs in patients with type 1 diabetes mellitus: A systematic review and meta-analysis. Diabetes research and clinical practice. 2017.129:213-223.
  • Tao H, Zhang Y, Li Q, Chen J. Methodological quality evaluation of systematic reviews or meta-analyses on ERCC1 in non-small cell lung cancer: a systematic review. Journal of cancer research and clinical oncology. 2017.143(11):2245-2256.
  • Ren P-W, Yang W-J, Wang D-D, Shan J-Y, Kang D-Y, Hong Q, Wen S, Zhang R-W. Kangfuxinye Enema Combined with Mesalamine for Ulcerative Colitis: A Systematic Review and GRADE Approach. Evidence-based complementary and alternative medicine : eCAM. 2017.2017:6019530-6019530.
  • Liu J, Li L, Li S, Jia P, Deng K, Chen W, Sun X. Effects of SGLT2 inhibitors on UTIs and genital infections in type 2 diabetes mellitus: a systematic review and meta-analysis. Scientific reports. 2017.7(1):2824-2824.
  • Liu J, Li L, Deng K, Xu C, Busse J W, Vandvik P O, Li S, Guyatt G H, Sun X. Incretin based treatments and mortality in patients with type 2 diabetes: systematic review and meta-analysis. BMJ (Clinical research ed.). 2017.357:j2499-j2499.
  • Chen Y, Du L, Li L, Ma J, Geng X, Yao X, Liu G, Sun X. Cancer risk of sulfonylureas in patients with type 2 diabetes mellitus: A systematic review. Journal of diabetes. 2017.9(5):482-494.
  • 周燕, 刘永军. 氟尿嘧啶缓释剂治疗结直肠癌的meta分析. 现代商贸工业. 2016.37(34):202-205.
  • 苏冠月, 喻佳洁, 李幼平. 益母草注射液促进产后子宫复旧效果的Meta分析. 中国循证医学杂志. 2016.16(11):1313-1321.
  • Zhou X, Yu J, Li L, Gloy V L, Nordmann A, Tiboni M, Li Y, Sun X. Effects of Bariatric Surgery on Mortality, Cardiovascular Events, and Cancer Outcomes in Obese Patients: Systematic Review and Meta-analysis. Obesity surgery. 2016.26(11):2590-2601.
  • Zhou X, Li L, Kwong J S W, Yu J, Li Y, Sun X. Impact of bariatric surgery on renal functions in patients with type 2 diabetes: systematic review of randomized trials and observational studies. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 2016.12(10):1873-1882.
  • Zhong D-k, Tang D, Xue L, Wen J, Li Y-p. Effectiveness of moxibustion for exercise-induced fatigue--a systematic review for randomized controlled trials. Chinese journal of integrative medicine. 2016.22(2):130-140.
  • Zhang L, Chen Q, Li L, Kwong J S W, Jia P, Zhao P, Wang W, Zhou X, Zhang M, Sun X. Alpha-glucosidase inhibitors and hepatotoxicity in type 2 diabetes: a systematic review and meta-analysis. Scientific reports. 2016.6:32649-32649.
  • Tan J, Cao Q, He G-L, Cai Y-H, Yu J-J, Sun X, Li Y-P. Misoprostol versus ergometrine-oxytocin for preventing postpartum haemorrhage: a systematic review and meta-analysis of randomized controlled trials. Journal of evidence-based medicine. 2016.9(4):194-204.
  • Qin T, Zhou X, Wang J, Wu X, Li Y, Wang L, Huang H, Li J. Hyperuricemia and the Prognosis of Hypertensive Patients: A Systematic Review and Meta-Analysis. Journal of clinical hypertension (Greenwich, Conn.). 2016.18(12):1268-1278.
  • Liu X-T, Ren P-W, Peng L, Kang D-Y, Zhang T-l, Wen S, Hong Q, Yang W-J. Effectiveness and safety of ShenXiong glucose injection for acute ischemic stroke: a systematic review and GRADE approach. BMC complementary and alternative medicine. 2016.16:68-68.
  • Li L, Li S, Liu J, Deng K, Busse J W, Vandvik P O, Wong E, Sohani Z N, Bala M M, Rios L P, Malaga G, Ebrahim S, Shen J, Zhang L, Zhao P, Chen Q, Wang Y, Guyatt G H, Sun X. Glucagon-like peptide-1 receptor agonists and heart failure in type 2 diabetes: systematic review and meta-analysis of randomized and observational studies. BMC cardiovascular disorders. 2016.16:91-91.
  • Li L, Li S, Deng K, Liu J, Vandvik P O, Zhao P, Zhang L, Shen J, Bala M M, Sohani Z N, Wong E, Busse J W, Ebrahim S, Malaga G, Rios L P, Wang Y, Chen Q, Guyatt G H, Sun X. Dipeptidyl peptidase-4 inhibitors and risk of heart failure in type 2 diabetes: systematic review and meta-analysis of randomised and observational studies. BMJ (Clinical research ed.). 2016.352:i610-i610.
  • 杨宗霞, 李筱, 王莉, 李幼平, 唐雪莉. 基本药物证据循证评价质量评价工具背景研究之一:基于随机对照试验系统评价的方法学质量评价工具. 中国循证医学杂志. 2015.15(06):723-729.
  • Yu J, Zhou X, Li L, Li S, Tan J, Li Y, Sun X. The long-term effects of bariatric surgery for type 2 diabetes: systematic review and meta-analysis of randomized and non-randomized evidence. Obesity surgery. 2015.25(1):143-158.
  • Yu J, Zhang C, Li L, Kwong J S W, Xue L, Zeng X, Tang L, Li Y, Sun X. Internal fixation treatments for intertrochanteric fracture: a systematic review and meta-analysis of randomized evidence. Scientific reports. 2015.5:18195-18195.
  • Mao X, Jia P, Zhang L, Zhao P, Chen Y, Zhang M. An Evaluation of the Effects of Human Factors and Ergonomics on Health Care and Patient Safety Practices: A Systematic Review. PloS one. 2015.10(6):e0129948-e0129948.
  • 喻佳洁, 王应强, 李幼平, 李向莲, 李萃萃, 沈建通. 达芬奇手术系统安全性和有效性的快速评估. 中国循证医学杂志. 2014.14(05):530-540.
  • 杨宗霞, 沈建通, 李幼平, 赵琨, 师成虎, 肖月, 喻佳洁, 郭武栋, 李萃萃, 王应强, 李向莲. 螺旋断层放疗系统治疗肿瘤的快速卫生技术评估. 中国循证医学杂志. 2014.14(09):1052-1069.
  • 王应强, 罗倩倩, 李幼平, 邓绍林, 李向莲, 韦诗友. 对射频消融术与肝切除术治疗小肝癌系统评价/Meta分析的方法学质量再评价. 中国循证医学杂志. 2014.14(05):561-574.
  • 陈建蓉, 王霁, 秦天强, 黄艳, 李静. 复方甘草酸苷治疗慢性乙型肝炎的效果及安全性的meta分析. 南方医科大学学报. 2014.34(08):1224-1229.
  • Zhang X, Kang D, Zhang L, Peng L. Shuganjieyu capsule for major depressive disorder (MDD) in adults: a systematic review. Aging & mental health. 2014.18(8):941-953.
  • Wang J, Qin T, Chen J, Li Y, Wang L, Huang H, Li J. Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. PloS one. 2014.9(12):e114259-e114259.
  • Peng L, Zhang X, Kang D-Y, Liu X-T, Hong Q. Effectiveness and safety of Wuling capsule for post stroke depression: a systematic review. Complementary therapies in medicine. 2014.22(3):549-566.
  • Li L, Shen J, Bala M M, Busse J W, Ebrahim S, Vandvik P O, Rios L P, Malaga G, Wong E, Sohani Z, Guyatt G H, Sun X. Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies. BMJ (Clinical research ed.). 2014.348:g2366-g2366.
  • 成岚, 陈雪, 袁强, 周昌华, 傅雪梅, 李幼平, 王乃红, 王莉. 血小板人白细胞抗原和/或人血小板抗原基因配型预防血小板输注无效的Meta分析. 中国医学科学院学报. 2012.34(01):71-76.
  • Huang Y, Li Y-L, Huang H, Wang L, Yuan W-M, Li J. Effects of hyperuricemia on renal function of renal transplant recipients: a systematic review and meta-analysis of cohort studies. PloS one. 2012.7(6):e39457-e39457.
  • Chen J, Yao Y, Chen H, Kwong J S W, Chen J. Shengmai (a traditional Chinese herbal medicine) for heart failure. The Cochrane database of systematic reviews. 2012.11:CD005052-CD005052.
  • 袁强, 陈雪, 成岚, 周昌华, 傅雪梅, 李幼平, 王乃红, 王莉. 白细胞滤过的血小板预防血小板输注无效和人类白细胞抗原同种免疫反应的Meta分析. 中国医学科学院学报. 2011.33(04):412-420.
  • 李雨璘, 王凌, 李静, 黄艳, 袁文明. 尿酸与肾脏疾病发生和预后关系的系统评价和荟萃分析. 中华内科杂志. 2011.50(7):555-561.
  • 李雨璘, 聂燕丽, 黄燕, 张鸣明, 李静. 患者参与患者安全的系统评价. 中国循证医学杂志. 2011.11(08):903-909.
  • 崔小花, 王莉, 李幼平, 邓绍林, 李廷谦, 商洪才. 六种含鱼腥草的注射制剂安全性与有效性评价. 中国循证医学杂志. 2011.11(07):799-804.
  • 崔小花, 王莉, 李幼平, 邓绍林, 李廷谦, 商洪才. 鱼腥草注射液治疗呼吸系统疾病有效性评价. 中国循证医学杂志. 2011.11(07):786-798.
  • Zheng H, Chen Y, Chen J, Kwong J, Xiong W. Shengmai (a traditional Chinese herbal medicine) for heart failure. The Cochrane database of systematic reviews. 2011. (2):CD005052-CD005052.
  • Zhang L-L, Zeng L-N, Li Y-P. Side effects of phenobarbital in epilepsy: a systematic review. Epileptic disorders : international epilepsy journal with videotape. 2011.13(4):349-365.
  • Yang X-Y, Chen Q-F, Li Y-P, Wu S-M. Mycobacterium vaccae as adjuvant therapy to anti-tuberculosis chemotherapy in never-treated tuberculosis patients: a meta-analysis. PloS one. 2011.6(9):e23826-e23826.
  • Turun S, Banghua L, Yuan Y, Zhenhui L, Ying N, Jin C. A systematic review of rivaroxaban versus enoxaparin in the prevention of venous thromboembolism after hip or knee replacement. Thrombosis research. 2011.127(6):525-534.
  • Nie Y, Li Y, Ning J, Hou Y, Huang Y, Zhang M. Patient safety research in China: a literature review. Journal of evidence-based medicine. 2011.4(2):66-72.
  • Nie Y, Li L, Duan Y, Chen P, Barraclough B H, Zhang M, Li J. Patient safety education for undergraduate medical students: a systematic review. BMC medical education. 2011.11:33-33.
  • Li L, Wen J, Wang L, Li Y P, Li Y. Is routine indwelling catheterisation of the bladder for caesarean section necessary? A systematic review. BJOG : an international journal of obstetrics and gynaecology. 2011.118(4):400-409.
  • Chen Q, Yang X, Li Y, He X, Ma X, Ma L, Guo Z, Li L. Preventive effects of Mycobacterium vaccae on HIV-associated tuberculosis: a systematic review. Journal of evidence-based medicine. 2011.4(2):122-129.
  • 袁强, 王莉, 成岚, 崔小花, 钟大可, 李媛媛, 商洪才, 张伯礼, 李幼平. 国家基本药物目录(2004年版)33种中药注射剂不良反应/不良事件文献分析. 中国循证医学杂志. 2010.10(02):132-139.
  • 成岚, 王莉, 袁强, 崔小花, 商洪才, 张伯礼, 李幼平. 双黄连注射剂不良反应文献评价. 中国循证医学杂志. 2010.10(2):140-147.
  • Yang X-Y, Li Y-P, Mei Y-W, Yu Y, Xiao J, Luo J, Yang Y, Wu S-M. Time and spatial distribution of multidrug-resistant tuberculosis among Chinese people, 1981-2006: a systematic review. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2010.14(10):e828-e837.
  • Yang X-y, Chen Q-f, Cui X-h, Yu Y, Li Y-p. Mycobacterium vaccae vaccine to prevent tuberculosis in high risk people: a meta-analysis. The Journal of infection. 2010.60(5):320-330.
  • Wang L, Cui X, Cheng L, Yuan Q, Li T, Li Y, Deng S, Shang H, Bian Z. Adverse events to Houttuynia injection: A systematic review. Journal of evidence-based medicine. 2010.3(3):168-176.
  • Wang L, Cheng L, Yuan Q, Cui X, Shang H, Zhang B, Li Y. Adverse drug reactions of Shuanghuanglian injection: a systematic review of public literatures. Journal of evidence-based medicine. 2010.3(1):18-26.
  • Li Y, Tang X, Zhang J, Wu T. Nutritional support for acute kidney injury. The Cochrane database of systematic reviews. 2010. (1):CD005426-CD005426.
  • Sun X, Briel M, Busse J W, Akl E A, You J J, Mejza F, Bala M, Diaz-Granados N, Bassler D, Mertz D, Srinathan S K, Vandvik P O, Malaga G, Alshurafa M, Dahm P, Alonso-Coello P, Heels-Ansdell D M, Bhatnagar N, Johnston B C, Wang L, Walter S D, Altman D G, Guyatt G H. Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials. Trials. 2009.10:101-101.
  • Sun X, Qin W-X, Li Y-P, Jiang X-H. Comparative cost-effectiveness of antiviral therapies in patients with chronic hepatitis B: a systematic review of economic evidence. Journal of gastroenterology and hepatology. 2007.22(9):1369-1377.
  • Chen J, Wu G, Li S, Yu T, Xie Y, Zhou L, Wang L. Shengmai (a traditional Chinese herbal medicine) for heart failure. The Cochrane database of systematic reviews. 2007. (4):CD005052-CD005052.